Gustav KLIMT, The Three Ages of a Woman, 1905
Gustav KLIMT, The Three 
Ages of a Woman, 1905 
International Conference on Progress in Bone and Mineral Research 2015 and the
Annual Autumn Conference of the Austrian Society for Bone and Mineral Research
on the occasion of the
Awarding of the "2015 International Research Prize"
Vienna, Austria
December 3-5, 2015
Download the BONE 2015 Programme
Thursday, December 3, 2015
09.00 - 10.30
Session 1
Chair: K. Klaushofer, T.J. Martin
09.00 - 09.05   Welcome Address
09.05 - 09.30   1.1 Osteo-Odyssey
P. Stern
09.30 - 10.00   1.2 Bone disease and systemic inflammation
E. Wagner
10.00 - 10.15   1.3 Relation between decreased IL-18BP levels and risk of osteoporosis in post menopausal osteoporotic patients: Role of IL-18BP in preventing bone loss by positively regulating Treg/Th17 balance
M. N. Mansoori, P. Shukla, A. M. Tyagi, K. Srivastava, M. Kakaji, K. B. Kumar, M. Dixit, J. Kureel, S. Gupta, D. Singh
10.15 - 10.30   1.4 Local gene expression in elderly women with osteoporotic hip fractures
U. Föger-Samwald, G. Vekszler, E. Hörz-Schuch, S. Salem, M. Wipperich, M. Mousavi, P. Pietschmann
10.30 - 11.00   Coffee Break & Poster Viewing
11.00 - 12.30   Session 2
Chair: P. Pietschmann, E. Wagner
11.00 - 11.30   2.1 Novel regulatory mechanism in osteoimmunology
H. Takayanagi
11.30 - 11.45   2.2 Serum levels of musculoskeletal markers of lung transplantation recipients
K. Kerschan-Schindl, A. Petrikic, U. Foeger-Samwald, W. Gruther, G. Ebenbichler, P. Pietschmann
11.45 - 12.00   2.3 Estrogen regulates bone turnover by targeting RANKL expression in bone lining cells
C. Streicher, A. Heyny, O. Andrukhova, B. Haigl, C. Schüler, K. Kollmann, I. Kantner, V. Sexl, M. Kleiter, L. C. Hofbauer, P. Kostenuik, R. G. Erben
12.00 - 12.30   2.4 Novel insights into the Glucocorticoid receptor in inflammation and bone integrity
J. Tuckermann
12.30 - 13.30   Lunch
13.30 - 15.00   Session 3
Chair: E. Kallay, P. Stern
13.30 - 14.00   3.1 The 3D structure of human lamellar bone and novel insights Into mineral formation processes
S. Weiner
14.00 - 14.10   3.2 Extracellular vesicles (EVs) as a shuttle of bioactive molecules: an efficient way of osteoblasts to smartly deliver Receptor Activator of Nuclear factor kappa-B Ligand (RANKL)
A. Cappariello, R. Paone, M. Muraca, N. Rucci, A. Teti
14.10 - 14.20   3.3 A comparative expression study of mineralizing and non-mineralizing osteoblast-like cells to identify genes involved in matrix vesicle formation
M. Blank, N. Hassler, S. Spitzer, E. P. Paschalis, K. Klaushofer, F. Varga
14.20 - 14.30   3.4 Bone and calcification specific microRNAs in patients with chronic kidney disease and renal transplantation
B. Obermayer-Pietsch, M. Ulbing, A. Kirsch, N. Schweighofer, B. Leber, S. Lemesch, A. Rosenkranz, H. Müller, K. Eller, V. Stadlbauer
14.30 - 14.40   3.5 Effects of L-mimosine on odontoblast markers and matrix mineralization in human dental pulp-derived cells
H. Müller, K. Janji?, B. Cvikl A. Moritz, H. Agis
14.40 - 14.50   3.6 Synchrotron µXRF analysis of Manganese distribution in antler and human bone
A. Turyanskaya, M. Rauwolf, A. Roschger, B. Pemmer, J. Prost, R. Simon, P. Roschger, J. G. Hofstaetter, T. Landete-Castillejos, C. Streli
14.50 - 15.00   3.7 The SOST knockout mouse model is more similar with Sclerosteosis in humans than previously known
U. Y. Schwarze, R. Gruber, T. Dobsak, F. L. Bookstein
15.00 - 15.30   Coffee Break & Poster Viewing
15.30 - 17.00   Session 4
Chair: E. Paschalis, S. Weiner
15.30 - 16.00   4.1 The mechanical interactions between collagen and mineral in bone
P. Fratzl
16.00 - 16.10   4.2 Effects of differing cortical pore size on total porosity and estimated bone strength
A. Zendeli, M. Kersh, Y. Bala, A. Ghasem Zadeh, E. Seeman, R. Zebaze
16.10 - 16.20   4.3 Transmenopausal changes in cortical bone quality
S. Gamsjaeger, W. Brozek, R. Recker, J. Lappe, K. Klaushofer, E. P. Paschalis
16.20 - 16.30   4.4 Distribution of Zinc in human high-grade osteosarcoma and healthy tissue determined with confocal synchrotron radiation micro X-Ray Fluorescence analysis
M. Rauwolf, B. Pemmer, A. Roschger, A. Turyanskaya, R. Simon, R. Windhager, K. Klaushofer, J. G. Hofstaetter, P. Roschger, C. Streli
16.30 - 16.40   4.5 Three-dimensional characterization of tibial and femoral bone microstructure in osteoarthritis patients using micro-computed tomography
S. Senck, J. Kastner, S. Hofstaetter, K. Trieb
16.40 - 17.00   4.6 Density and orientation of the osteocyte network in human osteons
F. Repp, P. Kollmannsberger, A. Roschger, P. Roschger, W. Wagermaier, P. Fratzl, R. Weinkamer
17.00 - 17.30   Coffee Break & Poster Viewing
17.30 - 18.50   Session 5
Chair: F. Varga, A. Teti
17.30 - 18.00   5.1 PTHrP, protein kinase A and CREB as drivers of osteosarcoma
T.J. Martin
18.00 - 18.10   5.2 The role of epidermal growth factor receptor in c-Fos-dependent osteosarcoma formation
M. Linder, S. Srivatsa, L. Bakiri, R. Plasenzotti, E. Wagner, M. Sibilia
18.10 - 18.20   5.3 Fgf23-driven pyrophosphate accumulation contributes to mineralization defect in Hyp mice
S. K. Murali, O. Andrukhova, R. G. Erben
18.20 - 18.30   5.4 Runx2 mediated transcriptional regulation of ST2 in the growth plate chondrocyte
E. Bonyadi Rad, K. Pichler, G. Musumeci, E. Marth, A. Weinberg, U. Schäfer
18.30 - 18.40   5.5 Coupling of angiogenesis and osteogenesis in bone
A. Kusumbe
18.40 - 18.50   5.6 Unloaded endothelial cells negatively affect bone formation in vitro and in vivo
V. Veeriah, M. Capulli, A. Zanniti, N. Rucci, A. Teti
18.50     Awarding of the "ÖGKM-Projektpreis" and"Herbert Czitober Forschungspreis" of the AusBMR
      Welcome Reception
Friday, December 4, 2015
09.00 – 10.30
Session 6
Chair: G. Karsenty, C. Muschitz
09.00 – 09.30   6.1 Leveraging an understanding of CaSR regulatory mechanisms for new approaches to treat disease
G. Breitwieser
09.30 – 09.40   6.2 The controversial role of the calcium-sensing receptor (CaSR) in cancer
E. Kallay
09.40 – 09.50   6.3 Dietary vitamin D3 prevents mouse prostate tumor progression induced by high calcium intake: a potential role for calcium sensing receptor and calcium channel TRPC6
T. Capiod
09.50 – 10.00   6.4 Altered Ca2+ signaling through plasma membrane Ca2+ ATPase in BRAF mutant melanoma and colon cancer cells
L. Hegedus, T. Garay, E. Molnar, K. Varga, M. Wolf, S. Torok, R. Padanyi, K. Paszty, M. Grusch, E. Kallay, B. Dome, W. Berger, B. Hegedus, A. Enyedi
10.00 – 10.10   6.5 Human neural calcium-sensing receptors (CaSRs) roles in Alzheimer’ disease
I. Dal Prà, U. Armato, E. Gardenal, D. Liu, A. Chiarini
10.10 – 10.20   6.6 Activating calcium sensing receptor mutations result in abnormally low bone matrix mineralization independent of parathyroid hormone deficiency
B. M. Misof, D. Ovejero-Crespo, R. Gafni, B. Brillante, H. Zhou, D. Dempster, J. Reynolds, J. Brahim, K. Klaushofer, P. Roschger, M. Collins
10.20 – 10.30   6.7 Identification and functional characterization of six novel CASR inactivating mutations in patients with FHH and PHPT syndromes
V. Guarnieri, L. Cinque, A. Sparaneo, G. Procino, S. Minisola, M. Battista, N. Cusano, G. N. Hendy, D. E. C. Cole, A. B. Scillitani
10.30 – 11.00     Coffee Break & Poster Viewing
11.00 – 12.00     Prize Awarding
Chair: H.P. Dimai, P. Pietschmann
11.30 – 12.00  
Awarding of the “2015 International Research Prize”
Calcium-Sensing Receptor Signalling Pathways in Health
and Disease
R.V. Thakker
Sponsored by 
12.00 – 13.00     Lunch
13.00 – 15.00     Session 7
Chair: G. Breitwieser, J. Zwerina
13.00 – 13.30   7.1 State-of-the-art in histomorphometry, including selected aspects of innovations in osteoporosis treatment
R.R. Recker
13.30 – 13.40   7.2 Characterization of bone tissue using a combination of backscattered electron microscopy and confocal laser scanning microscopy
A. Roschger, P. Roschger, F. Repp, W. Wagermaier, R. Weinkamer, K. Klaushofer, P. Fratzl
13.40 – 13.50   7.3 Genetic knock-out of sclerostin leads to improved bone mass and microarchitecture in a murine model of renal osteodystrophy
D. Cejka, R. Marculescu, I. Kramer, M. Kneissel, T. Gross, T. Reisinger, D. Pahr, M. Faugere, M. Haas, H. H. Malluche
13.50 – 14.00   7.4 Atypical femoral fractures - ongoing and history of bone specific therapy, concomitant diseases, medications and survival
C. Muschitz, H. W. Thaler, H. Dimai, H. Resch, R. Kocijan, C. Geiger, M. Kostic, A. Kaider, G. K. Muschitz, M. Szivak, P. Pietschmann
14.00 – 14.10   7.5 Bone quality of the newest bone formed after two years of teriparatide therapy in patients who were previously treatment-naïve or on long-term alendronate therapy
E. P. Paschalis, S. Gamsjaeger, B. Hofstetter, H. Dobnig, J. J. Stepan, H. Petto, I. Pavo, K. Klaushofer
14.10 – 14.20   7.6 Effects of the anabolic steroid stanozolol on bone metabolism in rats
E. Nebot Valenzuela, V. A. Aparicio, D. Camiletti-Moirón, R. Martinez, R. G. Erben, G. Kapravelou, C. Sánchez-González, C. De Teresa, J. M. Porres, M. López-Jurado, P. Aranda, P. Pietschmann
14.20 – 14.30   7.7 Effects of long-term alendronate treatment on postmenopausal osteoporosis bone material properties
N. Hassler, S. Gamsjaeger, B. Hofstetter, W. Brozek, K. Klaushofer, E. P. Paschalis
14.30 – 14.40   7.8 A micromechanical model to understand bone damage coupling in tension and compression
P. K. Zysset, J. Schwiedrzik, U. Wolfram
14.40 – 14.50   7.9 Alterations in bone material structure and properties during healing in rodents
W. Wagermaier, R. M. Hoerth, B. Willie, G. Duda, P. Fratzl
14.50 – 15.00   7.10 Cortical bone matrix mineralisation is decreased in TRPV4 deficient male, but not in female mice
P. Roschger, B. M. Misof, N. Fratzl-Zelman, J. G. J. Hoenderop, R. J. M. Bindels, J. P. T. M. van Leeuwen, K. Klaushofer, B. C. J. van der Eerden
15.00 – 15.30     Coffee Break & Poster Viewing
15.30 – 17.00     Session 8 – “Klaus Klaushofer Honorary Session”
Chair: P. Fratzl
19.30     Science meets Music
at Schlosstheater Schönbrunn upon the invitation of the Department of Voice and Musical Theatre,
University of Music and Performing Arts Vienna
including a Presidential Address on the occasion of the 25th Anniversary of AuSBMR
Saturday, December 5, 2015
09.00 – 10.30
Session 9
Chair: H.M. Kronenberg B. Svejda
Sponsored by Lilly
09.00 – 09.30   9.1 The regulation of osteoblast differentiation and functions by glucose
G. Karsenty
09.30 – 09.45   9.2 Lipocalin 2 deficiency unveils an interplay between bone homeostasis and energy metabolism in mice
N. Rucci, S. Gemini-Piperni, A. Maurizi, M. Capulli, A. Teti
09.45 – 10.00   9.3 Strategies for the reduction of loss of bone and body lean mass after bariatric surgery
C. Muschitz, R. Kocijan, J. Haschka, C. Marterer, A. Nia, A. Zendeli, G. K. Muschitz, H. Resch, P. Pietschmann
10.00 – 10.30   9.4 Diabetes & bone
P. Pietschmann
10.30 – 11.00     Coffee Break & Poster Viewing
11.00 – 12.30     Session 10
Chair: K. Kerschan-Schindl, H. Takayanagi
11.00 – 11.30   10.1 How PTH targets early cells of the osteoblast lineage
H.M. Kronenberg
11.30 – 11.45   10.2 Anabolic and anti-resorptive modulation of bone homeostasis by the epigenetic modulator sulforaphane, a naturally occurring isothiocyanate
R. Thaler, A. Maurizi, P. Roschger, I. Sturmlechner, S. Spitzer, M. Rumpler, H. Karlic, J. Zwerina, A. Dudakovic, K. Klaushofer, A. Teti, N. Rucci, A. J. van Wijnen, F. Varga
11.45 – 12.00   10.3 Mouse osteoblasts promote apoptosis and differentiation in human leukemic cells
F. Varga, S. Spitzer, K. Klaushofer, H. Karlic
12.00 – 12.30   10.4 Histones as an epigenetic platform for bone biology and disease
S. Kato
12.30 – 13.30     Lunch
13.30 – 15.00     Session 11
Chair: R. Gasser, K. Amrein
13.30 – 14.00   11.1 New experimental therapy for the autosomal dominant osteopetrosis type 2
A. Teti
14.00 – 14.10   11.2 LRP5-associated high bone mass disorder: novel familial mutation in LRP5 and investigation of bone mineralization density distribution (BMDD)
K. M. Roetzer, G. Uyanik, A. Brehm, J. Zwerina, S. Zandieh, T. Czech, P. Roschger, K. Klaushofer
14.10 – 14.20   11.3 A new small interfering RNA based therapy for the treatment of the autosomal dominant osteopetrosis, type 2: pre-clinical evidences
M. Capulli, A. Maurizi, N. Rucci, A. Teti
14.20 – 14.30   11.4 Differential acoustic mechanical behavior of periosteal and endostal bone between wild-type and Brtl/+ mice
S. Blouin, N. Fratzl-Zelman, W. A. Cabral, K. Klaushofer, P. Fratzl, J. C. Marini, P. Roschger
14.30 – 14.40   11.5 Increased heterogeneity of bone matrix mineralization in patients with X-linked hypophosphatemia
N. Fratzl-Zelman, P. Roschger, P. Plasenzotti, K. Nawrot-Wawrzyniak, M. Rumpler, G. Uyanik, G. Häusler, K. Klaushofer, E. Zwettler
14.40 – 14.50   11.6 Unique occurrence of long bone fragility with cranial hyperostosis: Searching for the genetic culprit
A. Raimann, U. Wintergerst, K. Klaushofer, M. Rasse, P. Roschger, R. Biedermann, R. Stelzl, F. Laccone, G. Haeusler
14.50 – 15.00   11.7 Identification of a novel PTH gene mutation in a family with Autosomal Dominant Hypoparathyroidism
E. Sanpaolo, V. Guarnieri, L. Penta, A. Verrotti, A. Sparaneo, P. Prontera
15.00 – 15.30     Coffee Break
15.30 – 17.20     Session 12
Chair: R.R. Recker, E. Zwettler
15.30 – 16.00   12.1 Endocrine and auto-/paracrine effects of Fgf23
R. G. Erben
16.00 – 16.10   12.2 Sclerostin levels and changes in bone metabolism after bariatric surgery
C. Muschitz, R. Kocijan, J. Haschka, C. Marterer, A. Nia, G. K. Muschitz, P. Pietschmann, H. Resch
16.10 – 16.20   12.3 TBS reflects trabecular microarchitecture in premenopausal women and similarly aged men with low traumatic fractures
C. Muschitz, R. Kocijan, J. Haschka, A. Kaider, D. Pahr, D. Hans, A. Fahrleitner-Pammer, H. Resch
16.20 – 16.30   12.4 Screening of biodegradable biomaterials for use in non-union bone lesions
C. Kampleitner, C. Richard, G. Hildebrand, K. Liefeith, C. González, J. Rodriguez-Cabello, A. Markus, C. Dullin, F. Alves, O. Hoffmann
16.30 – 16.40   12.5 Vitamin D Levels and Comorbidities in ambulatory and hospitalized patients in Austria
C. Muschitz, R. Kocijan, V. Stuetz, A. Kaider, G. K. Muschitz, H. Resch, S. Kapiotis
16.40 – 16.50   12.6 Gender-specific incidence of hip re-fractures among Austrian hip fracture patients
W. Brozek, B. Reichardt, J. Zwerina, H. Dimai, K. Klaushofer, E. Zwettler
16.50 – 17.05 12.7 Vitamin D and bone in critical illness
K. Amrein
17.05 – 17.10   12.8 International Conference – past and future
E. Preisinger
17.10 – 17.20     Closing Remarks
P 01 - Inherited Metabolic Dysfunction: Possible Cases of Mucopolysaccharidosis in a Mediaeval Population
M. Teschler-Nicola, K. M. Harkins, D. Schamall

P 02 - A case presenting with seizure who was diagnosed to have Infantile Hypophosphatasia
B. Ozcabi, G. Yesiltepe Mutlu, N. Eldes Hacihafizoglu, G. Akay Tayfun, S. Cici, G. Yesil, A. Bozaykut

P 03 - Calcium and vitamin D deficient Western-style diet promotes colitis-associated tumorigenesis in BALB/c mice.
C. Gröschel, S. Karuthedom, S. Tennakoon, A. Aggarwal, D. Heiden, L. Hegedüs, T. Manhardt, E. Bajna, E. Kállay

P 04 - Women in academic osteology

E. Schadelbauer, K. Amrein, A. Fahrleitner-Pammer

P 05 - Bone microarchitecture and bone metabolism in patients with hepatic cirrhosis: Preliminary data
R. Wakolbinger, A. Nia, H. Resch, P. Pietschmann, G. Scheriau, C. Muschitz

P 06 - Hypoparathyroidism and bone metabolism
M. Kern, H. P. Dimai, C. Trummer, A. Fahrleitner-Pammer, V. Schwetz, T. Pieber, K. Amrein

P 07 - The association between the presence of hepatic steatosis and decline of bone mineral density
H. Min, J. Yun, S. Kim, B. Cho, S. Lee, E. Chung

P 08 - Osteoporosis: where we come from and where we are going to
A. Bazarra-Fernandez

P 09 - A novel method for the assessment of joint space width and subchondral bone micro architecture
Ljuhar R, Norman B, Ljuhar D, Hladuvka J, Canhão H, Branco J, Rodrigues A, Gouveia N, Fahrleitner-Pammer A, Dimai HP


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